Table 1.
Radiobiologic Parameters of SiHa Cervical Cancer Cells (mean ± SEM).
Treatment | PE (%) | D0 (Gy) | Dq (Gy) | n | LD50 (Gy) | Dose Enhancement Ratio | LD10 (Gy) | Dose Enhancement Ratio | |
Oxic | Control | 50.6 ± 3.8 | 1.91 [0.16] | 2.46 [1.0] | 7.92 | 2.48 ± 0.48 | - | 5.26 ± 0.38 | - |
MG-132 | 38.1 ± 5.4 | 0.75 [0.39] | 1.51 [3.7] | 7.57 | 1.26 ± 0.25* | 1.96 ± 0.54 | 3.23 ± 0.32* | 1.63 ± 0.2 | |
3x Reoxygenation | 47.6 ± 4.2 | 0.9 [0.16] | 2.05 [1.1] | 11.18 | 1.63 ± 0.6 | 1.52 ± 0.64 | 3.9 ± 0.63 | 1.35 ± 0.24 | |
3x Reoxygenation MG-132 | 42.4 ± 6.4 | 0.7 [0.37] | 1.44 [3.5] | 7.95 | 1.16 ± 0.18* | 2.14 ± 0.53 | 3.01 ± 0.24* | 1.75 ± 0.19 | |
Hypoxia | Control | 44.8 ± 2.1 | 3.41 [0.98] | 0.81 [1.9] | 1.27 | 2.97 ± 0.11 | - | 8.5 ± 0.13 | - |
MG-132 | 41.7 ± 3.5 | 3.05 [1.14] | 1.84 [4.9] | 1.82 | 3.62 ± 0.44 | 0.82 ± 0.10 | 8.46 ± 0.36 | 1.00 ± 0.05 | |
3x Reoxygenation | 44.3 ± 10 | 3.63 [1.6] | 0.0 [3.7] | 1 | 2.52 ± 0.33 | 1.17 ± 0.15 | 8.4 ± 0.46 | 1.02 ± 0.06 | |
3x Reoxygenation MG-132 | 33.1 ± 1.8* | 2.46 [0.85] | 4.29 [1.1] | 5.74 | 5.2 ± 0.16* | 0.57 ± 0.03 | 9.47 ± 0.19* | 0.9 ± 0.02 | |
1x Reoxygenation | 47.2 ± 1.9 | 3.27 [1.3] | 1.56 [1.9] | 1.6 | 3.64 ± 0.13* | 0.86 ± 0.1 | 8.6 ± 0.20 | 0.99 ± 0.03 | |
15x Reoxygenation | 28.1 ± 1.1* | 1.96 [0.42] | 1.63 [1.0] | 2.3 | 2.45 ± 0.31 | 1.12 ± 0.09 | 6.1 ± 0.23* | 1.38 ± 0.06 |
Ninety-five percent confidence intervals are presented in square brackets.
P < .05.