Table 2.

Association of Heparanase Intensity and Extent of Staining with T Stage and Tumor Grade (Univariate Analysis).

T Stage	T0–2 [n (%)]	T3–4 [n (%)]	Total	P
Heparanase intensity
0	5 (50)	5 (50)	10	.049
1	12 (32)	25 (68)	37
2	4 (15)	23 (85)	27
Total	21	53	74
Heparanase extent
0	5 (50)	5 (50)	10	.027
1	6 (50)	6 (50)	12
2	10 (19)	42 (81)	52
Total	21	53	74
Grade	Carcinoma In Situ and Well-Differentiated Carcinoma [n (%)]	Moderately to Poorly Differentiated Carcinoma [n (%)]
Heparanase extent
0–1	8 (40)	12 (60)	20	.047
2	9 (18)	42 (82)	51
Total	17	52	71

Heparanase intensity: 0 = no staining; 1 = weak to moderate staining; 2 = strong staining.

Heparanase extent: 0, < 10% staining; 1, 10–50% staining; 2, > 50% staining.

Patients with no heparanase staining (0) were combined with the low-expressing group (1) for statistical analysis.