TABLE 1.
Mitochondrial mutator genes identified in the arg8m reversion assay
| Gene | Relative arg8m reversion ratea | Phenotype and/or functionb |
|---|---|---|
| YJR046w | 17 | Molecular function unknown, DNA replication licensing |
| YNL242w | 42 | Molecular function unknown, autophagy, peroxisome degradation |
| YOR279c | 34 | Peripheral membrane protein required for sporulation, molecular function unknown |
| YBL018c | 5 | Mitochondrial ribonuclease MRP |
| YPL188w (pos5) | 50 | Peroxide sensitive (this study) |
| YDL186w | 6 | Molecular and biological function unknown |
| Ngr1 | 6 | Negative growth regulatory protein |
| YDR295c | 11 | Molecular and biological function unknown |
| Hap2 | 6 | Heme-regulated transcription factor |
| YJL076w | 105 | Net1, Sir2-associated nucleolar protein required for rDNA silencing |
| Ecm10 | 509 | hsp70 homolog in the mitochondrial matrix |
| Can1 | 13,762 | Canavanine resistance, arginine permease |
a
Relative to the reversion rate of TF236.
b
During the course of this work, putative functions were assigned to several mitochondrial mutator genes by the Saccharomyces Genome Database (http://genome-www.stanford.edu/Saccharomyces/).