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. 2007 Feb;18(2):707–720. doi: 10.1091/mbc.E06-08-0680

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© 2007 by The American Society for Cell Biology

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Figure 8. — Model for the function of Rsp5 in the sorting of MVB cargoes via ubiquitin-dependent and alternative pathways. Rsp5 is responsible for the ubiquitination of a number of MVB cargoes, subsequently recognized by the ESCRTs to direct entry into the MVB pathway. Rsp5 can interact with Sna3 via WW-PPAY interactions, and this can lead to ubiquitination of Sna3 and ubiquitin-dependent recognition by ESCRTs. The interaction of Sna3 with Rsp5 appears to play an additional role in sorting via an alternate pathway that depends on Y15, presumably through the ubiquitination of an unknown sorting factor.