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Rapid turnover of Mvb12 by the proteasome depends on a functional MVB pathway. The translation inhibitor cycloheximide (50 mg/l) was added to yeast cultures (t = 0), and samples were taken after addition of the drug at the indicated time points. Cells were lysed using glass beads, and the resulting extracts were analyzed by Western blot for the presence of Vps23, Mvb12-HA, and Vps37-HA.
