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. 2007 Feb 1;117(2):304–306. doi: 10.1172/JCI31200

Figure 1. The CBF-A/KAP-1/FTS-1 complex is a master regulator of EMT.

Figure 1

In an epithelial cell undergoing EMT, the CBF-A and KAP-1 proteins recognize and bind to the FTS-1 sites in the genomic DNA. The CBF-A/KAP-1/FTS-1 complex controls the expression of a wide spectrum of EMT-responsive genes, possibly via the FTS-1 sites also present in their promoters. Arrows with + or – symbols indicate whether the abundance of a given protein is increased or decreased, respectively, via the action of the CBF-A/KAP-1/FTS-1 complex. ZO-1, zona occludens 1.