Table 1.

Parameters related to mitochondrial ATP production (state 3 conditions).

	Animal treatment
Parameter	Corn oil	TCDD
H2O2 production	57 ± 12	37 ± 18
O2 utilization	324 ± 27	586 ± 45*
RCR	4.3 ± 0.4	3.9 ± 0.5
Membrane potential	1.7 ± 0.2	1.6 ± 0.1
ATP production	469 ± 37	281.3 ± 18*
ATP/O ratio	1.45 ± 0.15	0.48 ± 0.11*
Hepatic ATP	6.2 ± 0.4	3.4 ± 0.3*

Liver mitochondria were prepared one week after treating male C57BL/6J mice with one dose of TCDD (5 μg/kg) or with corn oil vehicle. The units are: H₂O₂ production, pmol min⁻¹ mg protein⁻¹; O₂ utilization, nmol min⁻¹ mg protein⁻¹; RCR (respiratory control ratio), unitless; Membrane potential (JC-1 fluorescence ratio), unitless; ATP production, nmol min⁻¹ mg protein⁻¹; Hepatic ATP, nmol mg tissue⁻¹.

Data are presented as mean values ± S.E. (n = 6). A t-test was used to evaluate data.

^*P<0.05 versus vehicle-treated mice.