Table 1.

Synthesis of 5-hydroxy lactams (11–22) from dienyl tetronic acid derivatives

Reactant	Product	R	R1	% Yield
9	11	-CH3	H	98
9	12	-CH3	-CH2Ph	73
9	13	-CH3	n-butyl	80
9	14	-CH3	cyclopropyl	80
9	15	-CH3	iso-butyl	65
9	16	-CH3	n-hexyl	77
9	17	-CH3	n-octyl	73
9	18	-CH3	n-propyl	81
10	19	-CH2Ph	H	86
10	20	-CH2Ph	n-butyl	74
10	21	-CH2Ph	n-hexyl	73
10	22	-CH2Ph	-CH2Ph	82