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Both internal and external 
block are altered in T-338A-CFTR. Example single channel currents for wild-type (A) and T-338A-CFTR (B) recorded from inside out patches at membrane potentials of +50 mV and −50 mV, as indicated. In each case the closed state of the channel is indicated by the line on the far left. Currents were recorded in the absence of 
(control) or with 
present in the intracellular solution (100 μM) or the extracellular solution (1 mM).
