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. 2006 Dec 1;92(4):1241–1253. doi: 10.1529/biophysj.106.095349

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Concentration- and voltage dependence of block of T-338A-CFTR by ions. (A) Mean unitary current-voltage relationships for T-338A-CFTR, under control conditions (○) and in the presence of 1 mM (•) in the intracellular (left) or extracellular (right) solution. (B) Fractional unitary current remaining (i/i₀) after addition of different concentrations of to the intracellular (left) or extracellular (right) solution, at membrane potentials of −50 mV (•) and +50 mV (○). Each of these four sets of data has been fitted by Eq. 1. (C) Mean K_d calculated from curves such as those shown in B for both internal (•) and external (○) . Mean of data from 3–8 patches in each panel.

Inline graphic — Concentration- and voltage dependence of block of T-338A-CFTR by ions. (A) Mean unitary current-voltage relationships for T-338A-CFTR, under control conditions (○) and in the presence of 1 mM (•) in the intracellular (left) or extracellular (right) solution. (B) Fractional unitary current remaining (i/i₀) after addition of different concentrations of to the intracellular (left) or extracellular (right) solution, at membrane potentials of −50 mV (•) and +50 mV (○). Each of these four sets of data has been fitted by Eq. 1. (C) Mean K_d calculated from curves such as those shown in B for both internal (•) and external (○) . Mean of data from 3–8 patches in each panel.