TABLE 2.
Predicted distances between α-carbons of residues from neighboring subunits
| Tb-MscL residues | Crystal structure | Eco-mscL residues | SG model (closed) | SG model (open) | PM model (open) |
|---|---|---|---|---|---|
| R11 | 18.5 | R13 | 13.0 | 26.1 | N/A |
| G12 | 17.6 | G14 | 13.8 | 25.7 | 23.7 |
| N13 | 13.4 | N15 | 10.5 | 29.0 | 26.4 |
| I14 | 9.3 | V16 | 10.6 | 29.8 | 25.1 |
| V15 | 10.5 | V17 | 12.6 | 30.8 | 21.0 |
| D16 | 12.8 | D18 | 10.0 | 27.9 | 22.7 |
The distances between α-carbons of each specified residue from the two closest neighboring subunits. Measurements were made in M. tuberculosis using the published crystal structure coordinates (closed state) (14), the in E. coli SG model (closed and open states) (15,16), and in E. coli PM model (open state) (17) utilizing the ViewerLite program from Accelrys Software (San Diego, CA). All distances are in angstroms.