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Quaternary structural changes of SARS-CoV main protease in GdnCl. Continuous sedimentation analysis of the SARS-CoV main protease in the presence and absence of GdnCl. (A) Sedimentation of the enzyme in 30 mM Tris-Cl (pH 7.7) containing 0.4 M GdnCl. The sedimentation velocity data were analyzed with SEDFIT (17). The fitting residuals are shown under the panel. (B) C(s, f/fo) distribution of the enzyme in 0.4 M GdnCl. (C) C(s, f/fo) distribution of the enzyme in the absence of GdnCl.
