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GdnCl-induced dissociation and unfolding of SARS-CoV main protease. (Open circles) Remaining enzyme activity; (open triangles) remaining dimer percentage. Unfolding of the enzyme was demonstrated by the contour of continuous sedimentation coefficient and frictional ratio C(s, f/fo) with the most concentrated region shown in red. The x axis of these contours has no physical meaning.
