Table 2.
Top gene networks identified in Ingenuity Pathways analysis
| Region | Score | Focus genes | Wnt/β-catenin canonical pathway genes | Top biological functions |
|---|---|---|---|---|
| Ven DT | 24 | 18 | 0 | Cell-to-cell signaling and interaction, cellular assembly and organization, cellular function and maintenance |
| CM | 23 | 15 | 3 | Skeletal and muscular system development and function, cancer, cell cycle |
| Med DT | 33 | 21 | 2 | Embryonic development, cellular assembly and organization, cellular development |
| Pulv | 18 | 10 | 3 | Cell cycle, carbohydrate metabolism, small molecule biochemistry |
| An DT | 33 | 16 | 3 | Gene expression, cancer, cellular growth and proliferation |
Genes displaying region-specific expression were mapped to corresponding objects in the Ingenuity Pathways Knowledge Base. A score based on the number of mapped “focus” genes and network size is used for ranking purposes. The canonical Wnt/β-catenin signaling pathway was well represented among the top networks. An DT, anterior dorsal thalamus; CM, centre médian nucleus; Med DT, medial dorsal thalamus; Pulv, pulvinar; Ven DT, ventral dorsal thalamus.