Fig. 5.

Systemic immunosuppressive treatment of MOG_35–55/CFA/PTX-immunized mice with DEX significantly reduced glycolysis, as imaged with [¹⁸F]FDG. (A and B) Representative [¹⁸F]FDG PET/CT scans of mice immunized with MOG_35–55/CFA and of mice immunized with MOG_35–55/CFA/PTX, treated or not with DEX. Mice were imaged on days 7 (A) and 17 (B) after immunization. Before onset (day 7), changes in glycolysis were not sensitive to DEX treatment. (C) PTX alone can induce transient changes in glycolysis. Numbers of mice were as follows: MOG_35–55/CFA-immunized group, n = 14; PTX-immunized group, n = 5; MOG_35–55/CFA/PTX-immunized group untreated with DEX, n = 20; and MOG_35–55/CFA/PTX-immunized group treated with DEX, n = 11.