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. Author manuscript; available in PMC: 2007 Jan 30.
Published in final edited form as: Bioorg Med Chem Lett. 2006 Jul 7;16(18):4946–4950. doi: 10.1016/j.bmcl.2006.06.040

Table 2.

In vitro functional activity

Compound IC50a (nM)
MVD GPI/LMMP
1 b 26.4%e 11%e
7 b 34.9 ± 4.9 42.0 ± 16.3
7 33.3 ± 6.1f 108.0 ± 49.0g
Carboxyfentanyl 1% 1%
Fentanylc 9.45 ± 4.05 3.45 ± 0.45
Biphalind 0.72 ± 0.20 40.0 ± 13.0
a

Values are means of four experiments.

b

Tested in the base form.

c

Data according to Ref. 15.

d

Data according to Ref. 31.

e

Percent inhibition of agonist activity at 1 μM.

f

Small activity at κ-opioid receptors.

g

Effect is not reversed by naloxone.