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. 1999 Aug 31;96(18):10051–10055. doi: 10.1073/pnas.96.18.10051

Figure 5.

Figure 5

The recruitment of EKLF depends on a network of interactions between the LCR and the β-globin promoter. Arrows indicate that a protein or a protein complex was required for the recruitment of EKLF (black oval) to either 5′HS2 and 5′HS3 or the β-globin promoter. The arrows point to the recruited protein. Double-headed arrows indicate mutual dependence. The dashed arrow indicates that the recruitment of EKLF to 5′HS3 depends on the presence 5′HS2. The arrows only indicate dependence for recruitment as revealed by the PIN*POINT assay performed in this and other reports (C.-H.L., M. R. Murphy, J.-S.L., and J.H.C., unpublished work) and do not show all potential dependence for recruitment or imply direct interaction. The role of EKLF on recruitment of TATA-binding protein (TFIID) was derived from the results in another report (C.-H.L., M. R. Murphy, J.-S.L., and J.H.C., unpublished work). The striped oval indicates the complex on the 5′HSs, and the gray object indicates the SWI/SNF-related complex, such as EKLF coactivator-remodeling complex (E-RC1). The transcription initiation site is indicated with a bent arrow.