Table 2.
Prevalence of celiac disease in patients with anemia
| Study and year published | No. of patients | Positive by serology, % | Positive on biopsy, % | Comments |
|---|---|---|---|---|
| McIntyre and Long,38 1993 | 114 | n/a | 2.6 | IDA. Not all patients were biopsied. |
| Corazza et al,37 1995 | 200 | 8 | 5 | IDA. All patients with positive serology were biopsied. |
| Unsworth et al,42 2000 | 483 | 6.6 | 4.6 | Four hundred eighty-three of 1380 blood donors with anemia were offered serologic screening; the majority of anemic CD patients had IDA. Not all seropositive patients were biopsied. |
| Haslam et al,43 2001 | 216 | 2.3 | n/a | Pregnant women with anemia. Four of 5 anemic women with positive serology had IDA. |
| Howard et al,44 2002 | 258 | 10.9 | 4.7 | The majority of patients had IDA. Four percent had folate deficiency. Not all seropositive patients were biopsied. |
| Ransford et al,39 2002 | 484 | 3.5 | 2.3 | All patients with hypochromic and microcytic anemia. Not all seropositive patients were biopsied. |
| Studies using endoscopy and small-bowel biopsies in patients with IDA | ||||
| Bini et al,41 1998 | 186 | n/a | 0 | No patient was diagnosed with CD. |
| Kepczyk and Kadakia,40 1995 | 70 | n/a | 5.7 | Not all patients were biopsied. |
| Grisolano et al,45 2004 | 103 | n/a | 8.7 | All patients were biopsied. |
| Mandal et al,46 2004 | 504 | n/a | 1.8 | Not all patients were biopsied. |
n/a indicates not available.