Table 1.
Genes whose mutations or changes in expression occur recurrently in cytogenetically normal AML and have clinical significance
| Gene symbol (aliases and previous gene symbols) |
Gene name | Chromosomal location |
|---|---|---|
| FLT3 (STK1, FLK2, CD135) | Fms-related tyrosine kinase 3 | 13q12 |
| NPM1 (B23)* | Nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 5q35 |
| MLL (ALL-1, HRX, HTRX1, CXXC7, TRX1, MLL1A) | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 11q23 |
| BAALC | Brain and acute leukemia gene, cytoplasmic | 8q22.3 |
| CEBPA (CEBP) | CCAAT/enhancer binding protein (C/EBP), alpha | 19q13.1 |
| ERG | v-ets erythroblastosis virus E26 oncogene-like (avian) | 21q22.3 |