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. 2006 Sep 26;109(3):896–904. doi: 10.1182/blood-2006-06-027714

Table 2.

Patient characteristics and outcome on Protocol 95-01

Total 5-y EFS ± SE P
All patients 491 82 ± 2 —
DFCI risk group .01
    Standard 272 86 ± 2
    High 219 76 ± 3
NCI risk group, non-infants* .19
    Good-risk pre-B 299 86 ± 2
    Poor-risk pre-B 121 70 ± 4
    Good-risk T 12 83 ± 11
    Poor-risk T 40 85 ± 6
Age <.01
    Younger than 1.00 y 14 42 ± 13
    1.00-9.99 y 385 84 ± 2
    10.00-18.00 y 92 75 ± 5
WBC count <.01
    Less than 20.000 × 109/L 318 87 ± 2
    20.000-49.999 × 109/L 76 71 ± 5
    50.000-99.999 × 109/L 43 79 ± 6
    100.000 × 109/L or higher 54 66 ± 7
Sex .26
    Male 274 79 ± 3
    Female 217 84 ± 3
Immunophenotype .57
    B-lineage 434 81 ± 2
    T-cell 52 85 ± 5
CNS at diagnosis .16
    CNS-1 403 83 ± 2
    CNS-2 49 72 ± 7
    CNS-3 12 75 ± 13
    Traumatic 19 68 ± 11
Down syndrome .33
    No 477 82 ± 2
    Yes 14 71 ± 12
Ploidy in 309 assessable patients .12
    Hyperdiploid 50 or greater 82 86 ± 4
    Hyperdiploid less than 50 23 73 ± 9
    Diploid 134 84.3
    Pseudodiploid 54 71 ± 6
    Hypodiploid 16 73 ± 12
*

NCI age/WBC criteria11 used to define good-risk group (children 1 to <10 yr old with a leukocyte count <50 × 109/L) and poor risk group (all others) for both B-precursor and T-cell patients.