Table 1. .

Study Samples Used^[Note]

					No. of Subjects with				Total
Population	Study Design	No. of Families	No. of Studied Parents	No. of Unaffected Controls or Siblings	CPO	CLCP	CLO	Anomalya	Casesb	Samples
DBS	Case-control	755	0	485c	68			0	270	755
DCS	Case-parent	517	978	664d	101	201	156	70	529e	2,171
Iowa	Case-control triad	857	1,637	419c	110	157	103	42	445	2,501
Total		2,129	2,615	1,568	279	358	259	112	1,244	5,427

Note.— There were 202 subjects in the DBS who had either CLCP or CLO; the total number of subjects with CLCP and CLO was 819.

^aOCs that occur together with other anomalies, such as heart disease, extremity anomalies, or anomalies associated with syndromic OC.

^bCleft status is not known for some cases, so the numbers of cleft subphenotype will not add to the total number of cases.

^cUnaffected control.

^dUnaffected sibling.

^eA small proportion of families have multiple affected subjects. We randomly selected one affected child for the analysis.