Skip to main content
. 2006 Dec 7;80(1):76–90. doi: 10.1086/510518

Table A3. .

Effects of Offspring Genotypes[Note]

Denmark
 Iowa
 Combined
Gene/SNP and
Phenotype		 RR1 RR2 LRT
with
2 df
(P)		 R_A Additive
Model
LRT
with
1 df
(P)		 RR1 RR2 LRT
with
2 df
(P)		 R_A Additive
Model
LRT
with
1 df
(P)		 RR1 RR2 LRT
with
2 df
(P)		 R_A Additive
Model
LRT
with
1 df
(P)
CYP1B1_snp1:
 Alla 1.2 1.2 .53 1.1 .45 .7 .8 .03 1.0 .71 1.0 1.0 .54 1.0 .71
 CL/P 1.2 1.2 .60 1.1 .42 .6 .7 .05 .8 .22 .9 1.0 .72 1.0 1.00
 CPO 1.0 .9 .93 .9 .70 1.3 2.5 .04 1.7 .02 1.1 1.4 .37 1.2 .23
CYP1A1:
 Alla .6 .8 .03 .7 .01 .7 1.1 .20 .8 .17 .7 1.0 .006 .7 .007
 No anomaliesb .7 1.0 .11 .7 .068 .6 .8 .09 .7 .05 .7 .9 .01 .7 .008
CYP1A2:
 CPO 2.1 .8 .005 1.5 .05 1.4 1.2 .58 1.3 .41 1.7 1.3 .01 1.4 .03
GSTA4_snp2:
 No anomaliesb .7 .8 .007 .7 .01 1.0 1.4 .61 1.1 .61 .8 1.0 .04 .9 .11
 CLO .6 1.7 .005 .9 .40 .6 .5 .12 .6 .06 .6 1.2 .001 .8 .07
GSTM1_snp1:
 CPO 1.3 3.5 .02 1.7 .01 1.1 1.1 .98 1.1 .82 THRRc
GSTP1_snp3:
 Alla 1.1 1.0 .47 1.0 .86 1.2 .6 .01 .9 .19 THRRc
 CL/P 1.1 1.1 .60 1.0 .70 1.1 .5 .01 .8 .16 THRRc
NAT2_snp2:
 Alla .8 .6 .04 .8 .01 .8 .6 .12 .8 .04 .8 .6 .006 .8 .001
 No anomaliesb .8 .6 .07 .8 .02 .8 .6 .20 .8 .07 .8 .6 .01 .8 .003
 CL/P .8 .4 .01 .7 .01 .9 .6 .43 .8 .24 .8 .5 .007 .7 .002
 Control .7 .8 .01 .8 .02 1.0 .8 .67 .9 .43 .8 .8 .03 .8 .02

Note.— RR1 is the genetic RR when the child carries one copy of the variant allele; RR2 is that when the child carries two copies of the variant alleles; R_A is the RR when the child carries one copy of the variant allele, assumed to be a log additive model, a model in which the RR of carrying two copies of the variant alleles is the square of that of carrying one copy.

a

Includes data from all subjects with nonsyndromic OC.

b

Includes data from subjects without other minor anomalies.

c

For test of heterogeneity in RR (THRR), P<.05.