Table A4. .

Interactions between Fetal Genotype and Maternal Smoking^[Note]

	Danish			Iowa
Gene and Phenotype	C×E 1 (I1)	C×E 2 (I2)	C×E LRT (P)	CxE 1 (I1)	CxE 2 (I2)	C×E LRT (P)	Pa
EPHX1_snp1:
Allb	.82	.68	.62	.92	16.6	.004	.017
No anomaliesc	.94	.77	.87	.96	14.0	.01
GSTA4_snp1:
CPO	.20	1.78	.01	1.37	1.72	.78
GSTA4_snp2:
CPO	.23	3.63	.01	.78	2.60	.65
GSTP1_snp1:
CL/P	.50	1.94	.02	1.26	.86	.89
HIF1A:
Allb	.82	.37	.20	3.02	1.13	.02	.027
No anomaliesc	.82	.39	.28	2.89	1.19	.04
UG1A7_snp1:
Allb	2.30	1.44	.08	2.96	.53	.02	.014
No anomaliesc	2.14	1.63	.12	3.34	.53	.01
CPO	13.5	1.19	.02	4.94	.70	.25

Note.— I1 is the estimated interaction effect of one fetal copy of the variant allele together with maternal smoking; I2 is the estimated interaction effect of two fetal copies of the variant allele together with maternal smoking.

^aFor formal hypothesis testing, we used Fisher’s method to combine P values that were based on data from all OC cases in the Danish and Iowan populations.

^bIncludes data from all subjects with nonsyndromic OC.

^cIncludes data from subjects without other minor anomalies.