Table A8. .
Genes |
Gene-Smoking Interaction |
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Population | Offspring | Mother | Offspring | Mother |
Iowa | AhR_snp2, CYP1B1_snp1, CYP1A1, CYP1A2, GSTP1_snp3, NAT2_snp2, and NQO1 | CYP1A1, GSTM3, and NAT2_snp1 | EPHX1_snp1, GSTP1_snp2, HIF1A, UGT1A7_snp1, and GSTT1_del | EPHX1_snp1 and UGT1A7_snp1 |
DCS | CYP1A1, CYP1A2, GSTA4_SNP2, GSTM1_snp1, and NAT2_snp2 | EPHX1_snp1, GSTP1_snp3, NAT2_snp1, and UGT1A7_snp2 | CYP1B1_snp2, CYP1A1, EPHX1_snp2, GSTA4_snp1, GSTA4_snp2, GSTP1_snp3, GSTP1_snp1, and UGT1A7_snp1 | CYP2E1, GSTP1_snp3, HIF1A, NAT2_snp2, and UGT1A7_snp1 |
DBSa | CYP1A1 | NA | GSTT1_del | NA |
Note.— SNPs showing statistical significance in more than one population are shown in bold.
No maternal samples were available in the DBS sample set, so tests of maternal genotype or maternal genotype and smoking interaction effects were not applicable (NA). Only 9 (shown in table 3) of the 25 markers were genotyped in Danish case control samples.