Table 5. .
Allele Frequencies
| No. of Subjects with Allele | |||||||||||||||||||||||||
| Sample, Family Member, and Genotype | AHR_snp1 | AHR_snp2 | CYP1A1 | CYP1A2 | CYP1B1_snp1 | CYP1B1_snp2 | CYP2E1 | EPHX1_snp1 | EPHX1_snp2 | GSTA4_snp1 | GSTA4_snp2 | GSTM1_null | GSTM1_snp1 | GSTM3 | GSTP1_snp1 | GSTP1_snp2 | GSTP1_snp3 | GSTT1_null | HIF1A | NAT1_snp1 | NAT2_snp2 | NQO1 | SULT1A1 | UGT1A7_snp1 | UGT1A7_snp2 |
| DBS: | |||||||||||||||||||||||||
| Mothera: | |||||||||||||||||||||||||
| 11 | 534 | 250 | 555 | 330 | 140 | 449 | 428 | 311 | 392 | 236 | 425 | 307 | 181 | 320 | 296 | 560 | 219 | 570 | 420 | 196 | 312 | 425 | 194 | 82 | 262 |
| 12 | 110 | 315 | 85 | 279 | 348 | 189 | 186 | 278 | 222 | 293 | 207 | 343 | 223 | 280 | 267 | 91 | 309 | 83 | 198 | 323 | 299 | 191 | 245 | 256 | 299 |
| 22 | 1 | 74 | 2 | 42 | 163 | 13 | 25 | 55 | 36 | 115 | 24 | 73 | 37 | 84 | 4 | 115 | 35 | 134 | 43 | 20 | 97 | 227 | 78 | ||
| Fatherb: | |||||||||||||||||||||||||
| 11 | 461 | 218 | 453 | 303 | 113 | 360 | 356 | 286 | 365 | 217 | 399 | 255 | 165 | 268 | 255 | 493 | 142 | 492 | 374 | 215 | 280 | 354 | 215 | 68 | 223 |
| 12 | 92 | 273 | 89 | 210 | 293 | 186 | 168 | 235 | 190 | 287 | 162 | 313 | 203 | 238 | 246 | 79 | 288 | 76 | 169 | 246 | 238 | 193 | 212 | 238 | 241 |
| 22 | 9 | 73 | 9 | 43 | 162 | 20 | 34 | 39 | 17 | 59 | 14 | 0 | 55 | 43 | 69 | 1 | 128 | 0 | 21 | 109 | 52 | 12 | 61 | 191 | 92 |
| Control childc: | |||||||||||||||||||||||||
| 11 | 1,312 | 598 | 1,323 | 806 | 336 | 1,062 | 1,046 | 787 | 1,004 | 590 | 1,056 | 738 | 450 | 762 | 680 | 1,365 | 477 | 1,379 | 1,032 | 508 | 833 | 1,021 | 541 | 189 | 633 |
| 12 | 266 | 758 | 248 | 664 | 816 | 502 | 459 | 668 | 530 | 750 | 509 | 866 | 562 | 705 | 732 | 250 | 795 | 228 | 502 | 795 | 655 | 506 | 574 | 665 | 715 |
| 22 | 9 | 207 | 9 | 117 | 455 | 48 | 71 | 134 | 66 | 246 | 52 | 0 | 154 | 102 | 185 | 6 | 303 | 0 | 72 | 302 | 125 | 43 | 194 | 552 | 216 |
| DCS case: | |||||||||||||||||||||||||
| Case childd: | |||||||||||||||||||||||||
| 11 | 426 | 203 | 455 | 249 | 104 | 347 | 341 | 258 | 316 | 195 | 365 | 251 | 135 | 258 | 222 | 453 | 148 | 453 | 322 | 147 | 281 | 332 | 173 | 73 | 194 |
| 12 | 85 | 232 | 66 | 226 | 270 | 165 | 153 | 222 | 181 | 242 | 150 | 277 | 182 | 221 | 251 | 79 | 264 | 77 | 176 | 276 | 219 | 156 | 198 | 200 | 235 |
| 22 | 4 | 82 | 3 | 43 | 155 | 18 | 20 | 49 | 28 | 81 | 20 | 0 | 61 | 39 | 56 | 1 | 97 | 0 | 28 | 102 | 31 | 26 | 53 | 195 | 76 |
| Iowan control: | |||||||||||||||||||||||||
| Mothere: | |||||||||||||||||||||||||
| 11 | 293 | 139 | 288 | 192 | 66 | 274 | 260 | 196 | 270 | 132 | 248 | 171 | 103 | 173 | 150 | 310 | 134 | 306 | 230 | 118 | 174 | 243 | 185 | 65 | 119 |
| 12 | 77 | 170 | 81 | 139 | 219 | 116 | 119 | 163 | 99 | 184 | 124 | 213 | 179 | 175 | 155 | 77 | 178 | 77 | 147 | 192 | 160 | 93 | 116 | 159 | 164 |
| 22 | 3 | 53 | 6 | 23 | 110 | 5 | 9 | 20 | 12 | 57 | 21 | 46 | 34 | 41 | 2 | 70 | 14 | 65 | 36 | 23 | 42 | 145 | 54 | ||
| Fatherf: | |||||||||||||||||||||||||
| 11 | 267 | 122 | 261 | 183 | 66 | 226 | 235 | 178 | 218 | 113 | 219 | 150 | 106 | 150 | 127 | 293 | 107 | 273 | 214 | 100 | 181 | 189 | 141 | 51 | 108 |
| 12 | 62 | 151 | 68 | 113 | 171 | 124 | 97 | 141 | 109 | 167 | 115 | 189 | 143 | 152 | 140 | 53 | 168 | 67 | 115 | 182 | 135 | 111 | 115 | 141 | 152 |
| 22 | 2 | 38 | 6 | 18 | 125 | 12 | 18 | 29 | 16 | 52 | 19 | 0 | 46 | 23 | 43 | 3 | 64 | 0 | 18 | 57 | 16 | 16 | 39 | 131 | 46 |
| Childg: | |||||||||||||||||||||||||
| 11 | 1,531 | 739 | 1,497 | 993 | 386 | 1,387 | 1,288 | 1,002 | 1,317 | 655 | 1,299 | 862 | 543 | 942 | 773 | 1,705 | 672 | 1,558 | 1,208 | 622 | 993 | 1,221 | 815 | 344 | 603 |
| 12 | 373 | 884 | 398 | 700 | 993 | 610 | 589 | 810 | 598 | 907 | 663 | 1,066 | 738 | 822 | 824 | 327 | 924 | 380 | 710 | 993 | 774 | 567 | 681 | 848 | 801 |
| 22 | 17 | 250 | 33 | 150 | 672 | 69 | 79 | 158 | 87 | 305 | 87 | 0 | 272 | 145 | 245 | 11 | 342 | 0 | 90 | 331 | 144 | 87 | 246 | 687 | 354 |
| Iowan case: | |||||||||||||||||||||||||
| Motherh: | |||||||||||||||||||||||||
| 11 | 407 | 208 | 392 | 254 | 112 | 360 | 322 | 253 | 361 | 171 | 357 | 227 | 142 | 255 | 203 | 465 | 174 | 406 | 312 | 182 | 252 | 327 | 204 | 100 | 146 |
| 12 | 104 | 237 | 104 | 191 | 248 | 162 | 164 | 214 | 152 | 226 | 171 | 266 | 167 | 202 | 231 | 83 | 246 | 93 | 192 | 247 | 210 | 157 | 192 | 237 | 231 |
| 22 | 7 | 68 | 12 | 52 | 181 | 21 | 24 | 42 | 26 | 82 | 21 | 77 | 46 | 77 | 3 | 91 | 30 | 84 | 44 | 21 | 81 | 173 | 98 | ||
| Fatheri: | |||||||||||||||||||||||||
| 11 | 341 | 156 | 327 | 208 | 84 | 299 | 270 | 209 | 271 | 132 | 277 | 178 | 113 | 215 | 185 | 387 | 158 | 340 | 274 | 129 | 230 | 283 | 169 | 77 | 125 |
| 12 | 77 | 203 | 83 | 163 | 210 | 125 | 130 | 167 | 147 | 191 | 152 | 235 | 137 | 171 | 182 | 57 | 195 | 78 | 143 | 216 | 152 | 119 | 156 | 193 | 155 |
| 22 | 3 | 52 | 5 | 40 | 145 | 18 | 17 | 41 | 22 | 73 | 16 | 0 | 55 | 21 | 50 | 1 | 59 | 0 | 17 | 81 | 26 | 13 | 50 | 138 | 104 |
| Childj: | |||||||||||||||||||||||||
| 11 | 337 | 162 | 321 | 189 | 103 | 312 | 275 | 221 | 290 | 128 | 299 | 199 | 106 | 213 | 165 | 407 | 143 | 357 | 247 | 140 | 230 | 263 | 142 | 75 | 106 |
| 12 | 69 | 192 | 73 | 182 | 186 | 114 | 127 | 177 | 140 | 190 | 151 | 222 | 146 | 168 | 176 | 65 | 222 | 76 | 151 | 203 | 148 | 131 | 155 | 190 | 169 |
| 22 | 9 | 40 | 8 | 26 | 159 | 15 | 13 | 30 | 19 | 67 | 17 | 0 | 47 | 27 | 57 | 3 | 44 | 0 | 34 | 79 | 28 | 17 | 51 | 118 | 96 |
Allele/frequency: AHR_snp1/.087, AHR_snp2/.362, CYP1A1/.279, CYP1A2/.279, CYP1B1_snp1/.518, CYP1B1_snp2/.165, CYP2E1/.185, EPHX1_snp1/.301, EPHX1_snp2/.226, GSTA4_snp1/.406, GSTA4_snp2/.194, GSTM1_null/.528, GSTM1_snp1/.387, GSTM3/.278, GSTP1_snp1/.336, GSTP1_snp2/.076, GSTP1_snp3/.419, GSTT1_null/.127, HIF1A/.205, NAT1_snp1/.453, NAT2_snp2/.294, NQO1/.182, SULT1A1/.41, UGT1A7_snp1/.628, and UGT1A7_snp2/.356.
Allele/frequency: AHR_snp1/.098, AHR_snp2/.371, CYP1A1/.097, CYP1A2/.266, CYP1B1_snp1/.543, CYP1B1_snp2/.2, CYP2E1/.211, EPHX1_snp1/.279, EPHX1_snp2/.196, GSTA4_snp1/.36, GSTA4_snp2/.165, GSTM1_null/.551, GSTM1_snp1/.37, GSTM3/.295, GSTP1_snp1/.337, GSTP1_snp2/.071, GSTP1_snp3/.487, GSTT1_null/.134, HIF1A/.187, NAT1_snp1/.407, NAT2_snp2/.3, NQO1/.194, SULT1A1/.342, UGT1A7_snp1/.624, and UGT1A7_snp2/.382.
Allele/frequency: AHR_snp1/.089, AHR_snp2/.375, CYP1A1/.084, CYP1A2/.283, CYP1B1_snp1/.537, CYP1B1_snp2/.185, CYP2E1/.191, EPHX1_snp1/.295, EPHX1_snp2/.207, GSTA4_snp1/.392, GSTA4_snp2/.19, GSTM1_null/.54, GSTM1_snp1/.373, GSTM3/.29, GSTP1_snp1/.345, GSTP1_snp2/.081, GSTP1_snp3/.445, GSTT1_null/.142, HIF1A/.201, NAT1_snp1/.436, NAT2_snp2/.281, NQO1/.189, SULT1A1/.367, UGT1A7_snp1/.629, and UGT1A7_snp2/.367.
Allele/frequency: AHR_snp1/.09, AHR_snp2/.383, CYP1A1/.069, CYP1A2/.301, CYP1B1_snp1/.548, CYP1B1_snp2/.19, CYP2E1/.188, EPHX1_snp1/.302, EPHX1_snp2/.226, GSTA4_snp1/.39, GSTA4_snp2/.178, GSTM1_null/.525, GSTM1_snp1/.402, GSTM3/.289, GSTP1_snp1/.343, GSTP1_snp2/.076, GSTP1_snp3/.45, GSTT1_null/.145, HIF1A/.221, NAT1_snp1/.457, NAT2_snp2/.265, NQO1/.202, SULT1A1/.358, UGT1A7_snp1/.63, and UGT1A7_snp2/.383.
Allele/frequency: AHR_snp1/.111, AHR_snp2/.381, CYP1A1/.124, CYP1A2/.261, CYP1B1_snp1/.556, CYP1B1_snp2/.159, CYP2E1/.177, EPHX1_snp1/.268, EPHX1_snp2/.161, GSTA4_snp1/.399, GSTA4_snp2/.211, GSTM1_null/.555, GSTM1_snp1/.413, GSTM3/.318, GSTP1_snp1/.342, GSTP1_snp2/.104, GSTP1_snp3/.416, GSTT1_null/.201, HIF1A/.224, NAT1_snp1/.429, NAT2_snp2/.314, NQO1/.194, SULT1A1/.292, UGT1A7_snp1/.608, and UGT1A7_snp2/.404.
Allele/frequency: AHR_snp1/.1, AHR_snp2/.365, CYP1A1/.119, CYP1A2/.237, CYP1B1_snp1/.581, CYP1B1_snp2/.204, CYP2E1/.19, EPHX1_snp1/.286, EPHX1_snp2/.206, GSTA4_snp1/.408, GSTA4_snp2/.217, GSTM1_null/.558, GSTM1_snp1/.398, GSTM3/.305, GSTP1_snp1/.365, GSTP1_snp2/.085, GSTP1_snp3/.437, GSTT1_null/.197, HIF1A/.218, NAT1_snp1/.437, NAT2_snp2/.252, NQO1/.226, SULT1A1/.327, UGT1A7_snp1/.624, and UGT1A7_snp2/.399.
Allele/frequency: AHR_snp1/.106, AHR_snp2/.369, CYP1A1/.12, CYP1A2/.271, CYP1B1_snp1/.57, CYP1B1_snp2/.181, CYP2E1/.191, EPHX1_snp1/.286, EPHX1_snp2/.193, GSTA4_snp1/.406, GSTA4_snp2/.204, GSTM1_null/.553, GSTM1_snp1/0.413, GSTM3/.291, GSTP1_snp1/.357, GSTP1_snp2/.085, GSTP1_snp3/.415, GSTT1_null/.196, HIF1A/.222, NAT1_snp1/.425, NAT2_snp2/.278, NQO1/.198, SULT1A1/.337, UGT1A7_snp1/.591, and UGT1A7_snp2/.429.
Allele/frequency: AHR_snp1/.114, AHR_snp2/.364, CYP1A1/.126, CYP1A2/.297, CYP1B1_snp1/.564, CYP1B1_snp2/.188, CYP2E1/.208, EPHX1_snp1/.293, EPHX1_snp2/.189, GSTA4_snp1/.407, GSTA4_snp2/.194, GSTM1_null/.54, GSTM1_snp1/.416, GSTM3/.292, GSTP1_snp1/.377, GSTP1_snp2/.081, GSTP1_snp3/.419, GSTT1_null/.186, HIF1A/.236, NAT1_snp1/.404, NAT2_snp2/.294, NQO1/.197, SULT1A1/.371, UGT1A7_snp1/.572, and UGT1A7_snp2/.449.
Allele/frequency: AHR_snp1/.099, AHR_snp2/.373, CYP1A1/.112, CYP1A2/.296, CYP1B1_snp1/.569, CYP1B1_snp2/.182, CYP2E1/.197, EPHX1_snp1/.299, EPHX1_snp2/.217, GSTA4_snp1/.426, GSTA4_snp2/.207, GSTM1_null/.569, GSTM1_snp1/.405, GSTM3/.262, GSTP1_snp1/.338, GSTP1_snp2/.066, GSTP1_snp3/.38, GSTT1_null/.187, HIF1A/.204, NAT1_snp1/.444, NAT2_snp2/.25, NQO1/.175, SULT1A1/.341, UGT1A7_snp1/.575, and UGT1A7_snp2/.473.
Allele/frequency: AHR_snp1/.105, AHR_snp2/.345, CYP1A1/.111, CYP1A2/.295, CYP1B1_snp1/.563, CYP1B1_snp2/.163, CYP2E1/.184, EPHX1_snp1/.277, EPHX1_snp2/.198, GSTA4_snp1/.421, GSTA4_snp2/.198, GSTM1_null/.527, GSTM1_snp1/.401, GSTM3/.272, GSTP1_snp1/.364, GSTP1_snp2/.075, GSTP1_snp3/.379, GSTT1_null/.176, HIF1A/.253, NAT1_snp1/.428, NAT2_snp2/.251, NQO1/.201, SULT1A1/.369, UGT1A7_snp1/.556, and UGT1A7_snp2/.487.