Table 7. .
Two-Marker Haplotypes for the IL23R Gene[Note]
| Discovery Sample SetGlobal P=.004 |
Replication 1 Sample SetGlobal P=.002 |
Replication 2 Sample SetGlobal P=.003 |
Combined AnalysisGlobala Pcomb=4.14×10-6 |
||||||||||||
| Haplotype |
No. (Frequency) in |
No. (Frequency) in |
No. (Frequency) in |
||||||||||||
| rs7530511 | rs11209026 | Case (n=467) | Control (n=460) | OR | P | Case (n=498) |
Control (n=498) | OR | P | Case (n=481) | Control (n=424) | OR | P | ORcommon (95%CI)b | Pcomba |
| C | G | 796 (.852) | 730 (.793) | 1.50 | 9.48×10−4 | 840 (.843) | 794 (.797) | 1.37 | .006 | 824 (.857) | 682 (.804) | 1.45 | .003 | 1.44 (1.25–1.65) | 3.13×10−6 |
| T | G | 96 (.103) | 135 (.147) | .67 | .005 | 98 (.098) | 113 (.113) | .85 | .249 | 104 (.108) | 110 (.130) | .81 | .003 | .77 (.65–.91) | 3.22×10−4 |
| C | A | 42 (.045) | 55 (.060) | .74 | .134 | 56 (.056) | 89 (.089) | .61 | .004 | 34 (.035) | 56 (.066) | .52 | .153 | .62 (.49–.77) | .005 |
| T | A | 0 | 0 | … | … | 2 (.002) | 0 | … | … | 0 | 0 | … | … | … | … |
Note.— A pseudo-Gibbs sampling algorithm from the program SNPAnalyzer was used to estimate haplotype frequencies from unphased genotyping data, with cases and controls treated separately. The Haplo.Stats package was used to test for association between haplotypes and disease status.
a
Calculated using a Mantel-Haenszel common OR.
b
Calculated using Fisher’s combined test.