Table 1. .
Modes of Inheritance and Penetrance Values Used to Compute MAXHLOD
| Penetrancesb |
||||
| Genetic Modela |
Pr(aff/++) | Pr(aff/+d) | Pr(aff/dd) | Disease-Allele Frequency Pr(d)c |
| 1 | .0 | .5 | .5 | .02 |
| 2 | .0 | .8 | .8 | .01 |
| 3 | .0 | .0 | .5 | .20 |
| 4 | .0 | .0 | .8 | .16 |
a
Models correspond to autosomal dominant (models 1 and 2) and recessive (models 3 and 4) patterns of inheritance, with penetrance values of 50% (models 1 and 3) and 80% (models 2 and 4).
b
A plus sign (+) = wild-type allele at disease locus; d = disease allele at disease locus.
c
Pr(d) is altered in each model, to maintain a constant prevalence.