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Induction of chimerism gradually eliminated insulitis in diabetic NOD mice. Severity of insulitis in chimeric recipients given anti-CD3/CD8 conditioning and HCT, or nonchimeric NOD mice given conditioning only, were evaluated longitudinally. (A) Representative histopathology patterns of islets at different time points. (B) Percentage of residual islets with different level of insulitis at different time points. The mean of six examined mice is shown.
