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Donor CD4+T cell-depleted SPL and BM cells induced chimerism in overtly diabetic NOD mice conditioned with anti-CD3 and anti-CD8
| Conditioning | NOD mice | % chimeric recipients |
|---|---|---|
| Anti-CD3 | Prediabetic | 100 (8/8) |
| Diabetic | 25 (4/16) | |
| Anti-CD3/anti-CD8 | Prediabetic | 100 (8/8) |
| Diabetic | 96 (30/31) |
The percentage of donor-type cells among blood mononuclear cells from the chimeric recipients 8 weeks after HCT was usually >30%, and donor-type cells were not detectable in nonchimeric recipients.
