The PTEN C-terminal mutants map to predicted β-strands. The predicted secondary structures (SS), β-strand (b and double-headed arrows) and loop (L), are shown for PTEN and the variants, with point deletion (Δ) in position 319 or point mutations in positions 345 and 348. The changed amino acids and β-strands are shown in bold. The numbers indicate the probability, scaled from 0 to 9, for assigning β-strands (pr:b) by the program predictprotein from European Molecular Biology Laboratory, Heidelberg.