Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1972 May 20;2(5811):423–429. doi: 10.1136/bmj.2.5811.423

Treatment of Early Breast Cancer: A Report after Ten Years of a Clinical Trial

Hedley Atkins, J L Hayward, D J Klugman, A B Wayte
PMCID: PMC1788035  PMID: 4624222

Abstract

A controlled clinical trial has been carried out to compare radical mastectomy with wide excision (extended tylectomy) in the treatment of early breast cancer. Only patients aged 50 and over were included and 370 entered the trial during a period of 10 years. Postoperative radiotherapy was given in each case. In patients with clinically involved axillary nodes there was a significantly higher incidence of local and distant recurrence in those having a wide excision, and the survival of these patients was significantly less than those who had a radical mastectomy. In patients with clinically uninvolved nodes, although there was a significantly higher incidence of local recurrence in those having a wide excision, there was no increased incidence of distant recurrence and the survival rate was similar to those having a radical mastectomy.

Full text

PDF
429

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brinkley D., Haybittle J. L. Treatment of stage-II carcinoma of the female breast. Lancet. 1971 Nov 13;2(7733):1086–1087. doi: 10.1016/s0140-6736(71)90398-9. [DOI] [PubMed] [Google Scholar]
  2. Cole W. H., Mrazek R. G., Economou S. G., McDonald G. O., Slaughter D. P., Strehl F. W. Adjuvant chemotherapy. Cancer. 1965 Dec;18(12):1529–1535. doi: 10.1002/1097-0142(196512)18:12<1529::aid-cncr2820181203>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  3. Forrest A. P., Gleave E. N., Roberts M. M., Henk J. M., Gravelle I. H. A controlled trial of conservative treatment for early breast cancer. Proc R Soc Med. 1970 Feb;63(2):107–110. [PMC free article] [PubMed] [Google Scholar]
  4. Huvos A. G., Hutter R. V., Berg J. W. Significance of axillary macrometastases and micrometastases in mammary cancer. Ann Surg. 1971 Jan;173(1):44–46. doi: 10.1097/00000658-197101000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. JONES H. B. Demographic consideration of the cancer problem. Trans N Y Acad Sci. 1956 Feb;18(4):298–333. doi: 10.1111/j.2164-0947.1956.tb00453.x. [DOI] [PubMed] [Google Scholar]
  6. McKINNON N. E. Control of cancer mortality. Lancet. 1954 Jan 30;266(6805):251–254. doi: 10.1016/s0140-6736(54)90892-2. [DOI] [PubMed] [Google Scholar]
  7. NOER R. J. ADJUVANT CHEMOTHERAPY. THIO-TEPA WITH RADICAL MASTECTOMY IN THE TREATMENT OF BREAST CANCER. Am J Surg. 1963 Sep;106:405–412. doi: 10.1016/0002-9610(63)90123-5. [DOI] [PubMed] [Google Scholar]
  8. PARK W. W., LEES J. C. The absolute curability of cancer of the breast. Surg Gynecol Obstet. 1951 Aug;93(2):129–152. [PubMed] [Google Scholar]
  9. Winston B. M., Ellis F., Hall E. J. The Oxford NSD calculator for clinical use. Clin Radiol. 1969 Jan;20(1):8–11. doi: 10.1016/s0009-9260(69)80045-0. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES