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Southern and Western blot analyses of Gunn rat livers. Liver tissue was harvested for DNA and protein analysis 6 months after in vivo administration of the UGT1A1 ONs as described in Materials and Methods. (A) Southern blot analysis after sequential digestion of genomic DNA with EcoRI and BstNI. (B) Western blot analysis of total liver homogenate and microsomal extracts from the UGT1A1- and vehicle-treated Gunn rats. DNA size markers and protein molecular mass are indicated at left.
