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. 1999 Aug 31;96(18):10349–10354. doi: 10.1073/pnas.96.18.10349

Figure 6.

Figure 6

Effect of UGT1A1 gene correction on serum bilirubin levels in Gunn rats. Animals were administered UGT1A1 (blue squares) or nonspecific (red circles) ONs complexed to PEI or encapsulated in anionic liposomes as described in Materials and Methods. The dosage was repeated for all groups 30 days after the final injection of the first series (arrow). Each data point is the mean ± SD of 11 animals. There was no significant difference between the PEI and anionic liposome groups. P < 0.001 ≥14 days for UGT1A1 ONs.