Table 2.

Neutralization by B4 of PBMC-grown primary isolates and TCLA isolates of HIV-1

Virus strain	Virus subtype	Virus host	Assay host	Percent neutralization	mAb B4 concentration, μg/ml	Phenotype	Coreceptor
IIIB	B	H9	MT-2	90%	>100	TCLA	X4
MN	B	H9	MT-2	90%	67	TCLA	X4
VL069*	B	PBMC	MT-2	90%	>100	SI
VL135	B	PBMC	MT-2	90%	0.84	SI
VL114	B	PBMC	MT-2	90%	0.56	SI
VL172	B	PBMC	MT-2	90%	0.39	SI
VL750	B	PBMC	MT-2	90%	2.0	SI
UG/92/029	A	PBMC	MT-2	90%	3.9	SI
DH12	B	PBMC	MT-2	90%	1.9	SI
BR/92/014	B	PBMC	MT-2	90%	1.2	SI	R5X4
ZIM 748	C	PBMC	MT-2	90%	1.5	SI
UG266	D	PBMC	MT-2	90%	18	SI
TH 32036	E	PBMC	MT-2	90%	1.8	SI
BR/93/020	F	PBMC	MT-2	90%	15	SI	R5X4
92HT593	B	PBMC	PBMC	90%	0.29	SI	R5X4
92US714	B	PBMC	PBMC	90%	0.34	NSI	R5
92US727	B	PBMC	PBMC	90%	0.13	NSI	R5
92US660	B	PBMC	PBMC	90%	0.45	NSI	R5
91US056	B	PBMC	PBMC	90%	0.12	NSI	R5
91US054	B	PBMC	PBMC	90%	9.0	SI	R5
92US657	B	PBMC	PBMC	90%	3.0	NSI	R5
CVH	B	PBMC	PBMC	90%	2.0	NSI
AD-6	B	PBMC	PBMC	50%	0.25	NSI
VL135	B	PBMC	PBMC	90%	0.63	SI
US4	B	PBMC	PBMC	90%	0.16	NSI
DH12	B	PBMC	PBMC	90%	6.0	SI
CM238	E	PBMC	PBMC	50%	0.12	NSI
JV1083	G	PBMC	PBMC	90%	0.80	SI	R5
MN	B	PBMC	PBMC	90%	>100	TCLA	X4
CM237	B	PBMC	PBMC	90%	0.43	NSI	R5
US1	B	PBMC	PBMC	90%	1.2	NSI	R5
ZB18	C	PBMC	PBMC	90%	2.3	NSI
CM235	E	PBMC	PBMC	90%	0.95	NSI	R5
W25798	B	PBMC	PBMC	92%	1.0	NSI	R5
P59423	B	PBMC	PBMC	65%	1.0	NSI	R5
V89872	B	PBMC	PBMC	83%	1.0	SI	R5X4
V67970	B	PBMC	PBMC	95%	1.0	SI	R5X4

^*VL069 has phenotypic similarities to IIIB, such as rapid adaptation to growth in H9 cells.