Table 1.
Comparison of effects of hyperleptinemia induced by high fat feeding, by adenovirus-mediated leptin gene transfer, and by combination of high-fat feeding and adenovirus-induced hyperleptinemia on CSF leptin levels, on hypothalamic parameters (food intake and hypothalamic CART mRNA), and on adipocytes (body-fat mass and leptin mRNA)
| Response | Dietinduced | Adenovirusinduced | Diet- plus adenovirus-induced |
|---|---|---|---|
| CSF leptin levels | ↑ | ↑ | ↔ |
| Hypothalamus | |||
| Food intake (g) | ↓ | ↓ | ↔ |
| CART mRNA | ↑ | ↑ | ↔ |
| Adipocytes | |||
| Body fat | ↑ | ↓ | ↓ |
| Leptin mRNA | ↑ | ↓ | ↓ |