Table 1.

Phenotypic correction of murine hemophilia A

Recipient	FVIII activity	Anti-FVIII Ab	Survival
1	6700  ±  23	−	+
2	940  ±  65	−	+
3	650  ±  15	−	+
4	420  ±  8	−	+
5	280  ±  8	−	−
6	190  ±  3	−	+
7	72  ±  4	13  ±  0.3	−
8	54  ±  12	40  ±  0.5	−
9	−	7.0  ±  0.1	−
10	−	56  ±  12	−
11	−	64  ±  17	−
12	−	350  ±  39	−
13	−	−	−
PBS	−	−	−(0/6)

Mice were injected with concentrated VSV₂₉₃-FVIII (1–13) or PBS. FVIII activity (in mU/ml) at the time of tail-clipping is shown. Anti-FVIII antibodies (Ab) were determined by ELISA and Bethesda assays (in Bethesda units/ml). Undetectable FVIII or antibodies are indicated by a minus sign. Mice that survived (+) or died (−) after tail-clipping are shown. Values represent mean ± SEM.