Table 1.
Different variables observed 2 weeks after injection of streptozotocin or vehicle
| Long-Evans
|
Brattleboro
|
ANOVA
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cont, n = 8 | DM, n = 8 | DM/Cont | Cont, n = 7 | DM, n = 8 | DM/Cont | S | D | I | ||
| BW | g | 320 ± 3 | 264 ± 5*** | 0.83 | 286 ± 9 | 228 ± 6*** | 0.80 | c | c | |
| BW gain | g | 55 ± 3 | −1 ± 3*** | −0.01 | 11 ± 6 | −20 ± 6*** | −1.86 | c | c | a |
| Food intake | ml/day | 21 ± 1 | 29 ± 1*** | 1.38 | 20 ± 1 | 28 ± 1*** | 1.40 | c | ||
| Water intake | ml/day | 27 ± 1 | 121 ± 7*** | 4.48 | 203 ± 11 | 371 ± 29*** | 1.83 | c | c | a |
| Urine flow rate | ml/day | 16 ± 1 | 92 ± 6*** | 5.75 | 156 ± 11 | 309 ± 23*** | 1.98 | c | c | b |
| Urine osmolality | mOsm/kg H2O | 2337 ± 97 | 1443 ± 34*** | 0.62 | 191 ± 13 | 342 ± 15*** | 1.79 | c | c | c |
| Osm. exc. | mmol/day | 36 ± 1 | 132 ± 7*** | 3.67 | 29 ± 1 | 104 ± 5*** | 3.57 | c | c | a |
| Tc H2O | ml/day | 78 ± 2 | 304 ± 16*** | 3.90 | −66 ± 11 | −4 ± 16*** | 0.06 | c | c | c |
| Extr. water loss | ml/day | 12 ± 1 | 29 ± 3*** | 2.50 | 47 ± 4 | 72 ± 10*** | 1.55 | c | c | |
| Plasma osmolality | mOsm/kg H2O | 313 ± 1 | 336 ± 4*** | 1.07 | 328 ± 4 | 354 ± 5*** | 1.08 | c | c | |
| Posm–Pglu | mmol/liter | 302 ± 1 | 306 ± 4 | 1.01 | 319 ± 4 | 321 ± 4 | 1.01 | c | ||
Values are means ± SEM. BW gain, body weight gain between days 0 and 14; Osm. exc., osmolar excretion; Extr. water loss, extrarenal water losses; Posm, plasma osmolality; Pglu, plasma glucose concentration. ANOVA: S, strain effect; D, diabetes effect; I, interaction; a, P < 0.05; b, P < 0.01; c, P < 0.001. Fisher’s post hoc test: ∗∗∗, P < 0.001 vs. Cont in each strain.