Table 2.
Creatinine clearance and albumin excretion observed 2 and 4 weeks after injection of streptozotocin or vehicle
| Long-Evans
|
Brattleboro
|
ANOVA
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cont, n = 8 | DM, n = 8 | DM/Cont | Cont, n = 7 | DM, n = 8 | DM/Cont | S | D | I | ||
| Creatinine clearance, | 2 weeks | 2.50 ± 0.14 | 3.05 ± 0.14* | 1.22 | 2.29 ± 0.14 | 2.36 ± 0.21 | 1.03 | c | a | |
| ml/min | 4 weeks | 2.08 ± 0.08 | 3.19 ± 0.09** | 1.53 | 1.94 ± 0.16 | 1.67 ± 0.24 | 0.86 | c | b | c |
| Albumin excretion, | 2 weeks | 1.08 ± 0.03 | 2.21 ± 0.16*** | 2.05 | 1.21 ± 0.33 | 1.62 ± 0.13*** | 1.34 | c | a | |
| mg/day | 4 weeks | 0.74 ± 0.04 | 2.45 ± 0.19*** | 3.30 | 1.57 ± 0.28 | 1.78 ± 0.20 | 1.13 | c | c | |
Values are means ± SEM. ANOVA: S, strain effect; D, diabetes effect; I, interaction; a, P < 0.05; b, P < 0.01; c, P < 0.001. Fisher’s post hoc test: ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001 vs. Cont in each strain.