Table 3.

Glucose handling 2 weeks after injection of streptozotocin (DM) or vehicle (Cont)

		Long-Evans			Brattleboro			ANOVA
		Cont, n = 8	DM, n = 8	DM/Cont	Cont, n = 7	DM, n = 8	DM/Cont	S	D	I
Plasma glucose	mmol/liter	10.5  ±  0.1	30.6  ±  2.0***	2.91	9.8  ±  0.1	32.8  ±  2.1***	3.35		c
Urine glucose	mmol/liter	1.5  ±  0.1	764.0  ±  12.0***		0.0  ±  0.0	149.0  ±  7.0***		c	c	c
U/P		0.1	25.0		-	4.5
Glucose filtered	mmol/day	38  ±  1	135  ±  8***	3.53	32  ±  2	108  ±  9***	3.34	a	c
Glucose reabsorbed	mmol/day	38  ±  1	72  ±  8***	1.88	32  ±  2	70  ±  10***	2.15		c
Glucose excreted	mmol/day	0  ±  0	63  ±  9***		0  ±  0	39  ±  5***		a	c	a

Values are means ± SEM. ANOVA: S, strain effect; D, diabetes effect; I, interaction; a, P < 0.05; c, P < 0.001. Fisher’s post hoc test: DM vs. Cont: ∗∗∗, P < 0.001 vs. Cont in each strain.