Table 1.
Genotype | OFQ/N receptor binding
|
Plasma corticosterone
|
||||||
---|---|---|---|---|---|---|---|---|
Kd, pM | n | Bmax, fmol/mg protein | n | Basal, ng/ml | n | Mild stress, ng/ml | n | |
OFQ/N+/+ | 108 ± 38 | 4 | 251 ± 81 | 4 | 23.6 ± 4.9 | 12 | 195 ± 8.2 | 10 |
OFQ/N−/− | 114 ± 45 | 4 | 272 ± 64 | 4 | 42.3 ± 2.2* | 14 | 257 ± 14.0* | 14 |
Values are mean ± SEM. ∗, P < 0.02 OFQ/N−/− versus wild type. Kd, dissociation constant; Bmax, maximal receptor-binding capacity.