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. 2007 Jan 29;7:3. doi: 10.1186/1471-2377-7-3

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Copyright © 2007 Sparks et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of α-dystroglycan in quadriceps muscle from HIBM patients. A-F. Immunohistochemistry using antibodies to IIH6. No consistent difference in staining was apparent before (A,C,E) compared with after (B,D,F) IVIG treatment. The specimen shown in A was sampled from a deteriorating area. G. Immunoblots of muscle from a normal individual (N) and HIBM patients 1, 2, and 4, labeled with antibodies to α-dystroglycan. No consistent difference in IIH6 staining (reflecting the sialylation status of α-dystroglycan) was apparent before (Pre) compared with after (Post) IVIG treatment. β-Actin bands provide an indication of the level of protein loading.