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. Author manuscript; available in PMC: 2007 Feb 5.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2005;70:1–9. doi: 10.1101/sqb.2005.70.039

Figure 1.

Figure 1

Oncogenic K-ras is required for lung tumor maintenance with or without loss of tumor suppressor genes. Samples of lung tissue, stained with hematoxylin and eosin, after exposure to doxycycline for 1 or 2 months and after withdrawal for 7 days are shown (Fisher et al. 2001). Withdrawal of doxycycline leads to rapid tumor regression in bi-transgenic CCSP-rtTA/TetOKrasG12D in a wild-type (WT) background (A) and in an Ink4A/Arf-deficient background (B). Similar results were obtained in a p53-deficient background (Fisher et al. 2001). Magnification, 100x.