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. 1999 Aug 31;96(18):10489–10494. doi: 10.1073/pnas.96.18.10489

Figure 4.

Figure 4

(A) Cross-linking of T7 coliphage DNA by the hydroquinone intermediates of MC (□) or POR (▴). Generation of the hydroquinone intermediates was accomplished by reduction of 40 μM of each drug with 200 μM sodium borohydride as described in Materials and Methods. (B) The effects of oxygen on T7 coliphage DNA cross-linking by 40 μM sodium borohydride-reduced MC after 6 min of exposure time; hypoxia was created as described in Materials and Methods. Values represent the means of three independent determinations. SEMs are shown where large enough to be visible.