Table 2.
Clinical characteristics of colorectal cancer patients and GSTT2 genotypes
| -537 G>A | -277T>C | -158G>A | |||||||||||||
| GG (%) | GA (%) | AA (%) | p 1 | GA+AA (%) | p 2 | TT (%) | TC (%) | CC (%) | p 1 | TC+CC (%) | p 2 | TT (%) | TC (%) | p 2 | |
| No. of subjects | 127 | 240 | 69 | 309 | 388 | 45 | 3 | 48 | 416 | 20 | |||||
| Age (years ± SD) | 59.1 ± 13.2 | 58.91 ± 13.0 | 57.9 ± 12.2 | 0.83 | 58.7 ± 12.8 | 0.76 | 58.6 ± 13.0 | 60.0 ± 11.7 | 66.5 ± 2.1 | 0.56 | 60.3 ± 11.5 | 0.41 | 58.8 ± 13.0 | 58.2 ± 11.7 | 0.85 |
| Sex (M/F) | |||||||||||||||
| Male | 81 (64.8) | 151 (63.4) | 44 (63.8) | 0.97 | 195 (63.5) | 0.8 | 247 (64.2) | 27 (60.0) | 2 (100) | 0.49 | 29 (61.7) | 0.74 | 262 (63.4) | 14 (73.7) | 0.36 |
| Female | 44 (35.2) | 87 (36.6) | 25 (36.2) | 112 (36.5) | 138 (35.8) | 18 (40.0) | - | 18 (38.3) | 151 (36.6) | 5 (26.3) | |||||
| Location | |||||||||||||||
| proxim al | 48 (39.3) | 84 (35.6) | 19 (29.7) | 0.43 | 103 (34.3) | 0.33 | 135 (36.0) | 15 (33.3) | 1 (50.0) | 0.86 | 16 (34.0) | 0.79 | 141 (35.0) | 10 (52.6) | 0.18 |
| distal | 74 (60.7) | 152 (64.4) | 45 (70.3) | 197 (65.7) | 240 (64.0) | 30 (66.7) | 1 (50.0) | 31 (66.0) | 262 (65.0) | 9 (47.4) | |||||
| MSI status | |||||||||||||||
| MSI | 17 (13.9) | 35 (14.8) | 10 (14.5) | 0.97 | 45 (14.8) | 0.83 | 52 (13.6) | 10 (23.8) | - | 0.17 | 10 (22.7) | 0.1 | 59 (14.4) | 3 (17.6) | 0.71 |
| MSS | 105 (86.1) | 201 (85.2) | 59 (85.5) | 260 (85.2) | 331 (86.4) | 32 (76.2) | 2 (100) | 34 (77.3) | 351 (85.6) | 14 (82.4) | |||||
| T-stage | |||||||||||||||
| T1 | - | 2 (0.9) | 2 (3.1) | 0.11 | 4 (1.3) | 0.39 | 4 (1.1) | - | - | 0.95 | - | 0.74 | 4 (1.0) | - | 0.9 |
| T2 | 8 (6.5) | 8 (3.4) | 2 (3.1) | 10 (3.3) | 15 (4.0) | 3 (6.8) | - | 3 (6.5) | 17 (4.2) | 1 (5.3) | |||||
| T3 | 102 (82.3) | 195 (83.0) | 56 (86.1) | 251 (83.4) | 317 (83.6) | 34 (77.3) | 2 (100) | 36 (78.3) | 336 (82.8) | 17 (89.5) | |||||
| T4 | 14 (11.3) | 30 (12.8) | 5 (7.7) | 35 (11.6) | 42 (11.1) | 7 (15.9) | - | 7 (15.2) | 48 (11.8) | 1 (5.3) | |||||
| N-stage | |||||||||||||||
| N0 | 58 (46.8) | 119 (50.4) | 35 (53.0) | 0.31 | 154 (51.0) | 0.54 | 189 (49.7) | 23 (52.3) | - | 0.13 | 23 (50.0) | 0.55 | 200 (49.1) | 12 (63.2) | 0.38 |
| N1 | 36 (29.0) | 75 (31.8) | 14 (21.2) | 89 (29.5) | 114 (30.0) | 9 (20.5) | 2 (100) | 11 (23.9) | 122 (30.0) | 3 (15.8) | |||||
| N2 | 30 (24.2) | 42 (17.8) | 17 (25.8) | 59 (19.5) | 77 (20.3) | 12 (27.3) | - | 12 (26.1) | 85 (20.9) | 4 (21.1) | |||||
| M-stage | |||||||||||||||
| M0 | 90 (74.4) | 182 (78.1) | 52 (78.8) | 0.69 | 234 (78.3) | 0.39 | 293 (78.3) | 30 (68.2) | 1 (50.0) | 0.21 | 31 (67.4) | 0.1 | 311 (77.6) | 13 (68.4) | 0.35 |
| M1 | 31 (25.6) | 51 (21.9) | 14 (21.2) | 65 (21.7) | 81 (21.7) | 14 (31.8) | 1 (50.0) | 15 (32.6) | 90 (22.4) | 6 (31.6) | |||||
| TNM stage | |||||||||||||||
| I | 6 (5.0) | 10 (4.3) | 3 (4.6) | 0.94 | 13 (4.4) | 0.69 | 16 (4.3) | 3 (6.8) | - | 0.37 | 3 (6.5) | 0.2 | 18 (4.5) | 1 (5.3) | 0.46 |
| II | 42 (34.7) | 93 (40.1) | 28 (43.1) | 121 (40.7) | 145 (39.0) | 18 (40.9) | - | 18 (39.1) | 154 (38.6) | 9 (47.4) | |||||
| III | 42 (34.7) | 78 (33.6) | 20 (30.8) | 98 (33.0) | 130 (34.9) | 9 (20.5) | 1 (50.0) | 10 (21.7) | 137 (34.3) | 3 (15.8) | |||||
| IV | 31 (25.6) | 51 (22.0) | 14 (21.5) | 65 (21.9) | 81 (21.8) | 14 (31.8) | 1 (50.0) | 15 (32.6) | 90 (22.6) | 6 (31.6) | |||||
Student's t-test or χ2 test; p1: Co-dominant model; p2: Dominant model