Table 2.
Genes implicated in MK differentiation by virtue of a temporal expression pattern that correlates best with that of CD41
| Gene symbol | Gene name | Accession no. |
|---|---|---|
| G-protein–coupled signaling | ||
| Rgs10 | Regulator of G-protein signaling 10 | NM_026418 |
| Rgs18 | Regulator of G-protein signaling 18 | NM_022881 |
| Gpr56 | G-protein–coupled receptor 56 | NM_018882 |
| Ptger3 | Prostaglandin E receptor 3 (subtype EP3) | NM_011196 |
| Ptgir | Prostaglandin I receptor (IP) | AV373771 |
| Gnaz | Guanine nucleotide-binding protein, alpha z subunit | AI326356 |
| Gna13 | Guanine nucleotide-binding protein, alpha 13 | NM_010303 |
| Small GTPase-mediated signal transduction | ||
| Rab10 | RAB10, member RAS oncogene family | BF465974 |
| Rab11a | RAB11a, member RAS oncogene family | BI083615 |
| Rab6 | RAB6, member RAS oncogene family | BB699846 |
| Rab27b | RAB27b, member RAS oncogene family | NM_030554 |
| Kras2 | Kirsten rat sarcoma oncogene 2, expressed | BC010202 |
| Cdc423p5 | CDC42 effector protein (Rho GTPase binding) 5 | NM_021454 |
| Cell communication | ||
| Itga2b | Integrin alpha 2b | NM_010575 |
| Lims1 | LIM and senescent cell antigen-like domains 1 | BM213930 |
| Col18a1 | Procollagen, type XVIII, alpha 1 | NM_009929 |
| Gp1ba | Glycoprotein 1b, alpha polypeptide | NM_010326 |
| Gp1bb | Glycoprotein 1b, beta polypeptide | NM_010327 |
| Plek | Pleckstrin | NM_019549 |
| Itga4 | Integrin alpha 4 | NM_010576 |
| Stim1 | Stromal interaction molecule 1 | NM_009287 |
| Esa1 | Endothelial-cell–selective adhesion molecule | AF361882 |
The results represent analysis of variance (ANOVA) across all tested MK differentiation stages (ie, MK-P, MK-3, and MK-6). This table highlights the 22 transcripts (out of a total of 386 CD41-correlated genes) implicated in G-protein–coupled signaling, small GTPase-mediated signal transduction, or cell communication.