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DSP1 has opposite effects on Dorsal-mediated transcriptional activation on the twist and zen promoters. HeLa cells were cotransfected with plasmids expressing DSP1 and Dorsal and the depicted reporter gene. (a) DSP1 helps Dorsal-mediated activation of the twist promoter. (b) DSP1 inhibits Dorsal activity from the zen promoter. (c) DSP1 helps Dorsal to activate transcription from the minimal ventral enhancer elements of the twist promoter.
