Table 1.
H. sapiens Recon 1 network statistics
| Component | Number |
|---|---|
| Genes | 1,496 |
| Transcripts* | 1,905 |
| Proteins | 2,004 |
| Complex-associated reactions* | 248 |
| Isozyme-associated reactions* | 946 |
| Intrasystem reactions | 3,311 |
| Metabolic | 2,233 |
| Transport† | 1,078 |
| Exchange reactions† | 432 |
| Compartment-specific metabolites | 2,712 |
| Cytoplasm | 995 |
| Extracellular space | 388 |
| Mitochondrion | 383 |
| Golgi apparatus | 279 |
| Endoplasmic reticulum | 231 |
| Lysosome | 207 |
| Peroxisome | 139 |
| Nucleus | 90 |
| Citations | 1,587 |
| Primary literature | 1,378 |
| Review articles | 188 |
| Textbooks | 21 |
| Validated metabolic functions | 288 |
| Knowledge gaps‡ | 356 |
*See Materials and Methods for definitions of transcripts, complexes, and isozymes.
†Transport reactions refer to intrasystem transport across a boundary (organellar and plasma membranes), whereas exchange reactions describe metabolite transport across the system boundary, e.g., into and out of the extracellular space from the surrounding medium.
‡Number of “dead-end” metabolites only produced or consumed.