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Electron micrographs of hDmc1. (a) Forming rings in the absence of DNA. (b) Clusters of rings with ssDNA. (c) Stacks of double rings on partially duplex φX174. In the absence of DNA (a) the rings appear to be uniformly distributed, with very little aggregation. In contrast, when ssDNA is added, the rings frequently are clumped together. Four such aggregates can be seen in b. The formation of the long stacks of rings (c) seems to require a ss-dsDNA junction. (Scale bar = 1,000 Å.)
