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Effects of ‘wild-type like' FALS-linked mutations on SOD1 folding. Kinetics of acquisition of resistance of FALS-linked ‘wild-type-like' mutants to 0.01 mg/ml (A) and 1 mg/ml (B) proteinase K. Inset, initial rates of protease resistance for WT-SOD1 and mutants fitted to a linear least-squares regression model. Graphical data are mean±s.e.m. from a minimum of three independent experiments per time point.
