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Changes in osteocalcin (OCN)/GAPDH mRNA with age. The relative OCN/GAPDH ratios were determined in intertrochanteric trabecular bone from individuals with osteoarthritis (OA) (n = 15) and control individuals (n = 13). In OA, OCN/GAPDH mRNA increased significantly with age (OCN/GAPDH = 0.01 [Age] + 0.43; r = 0.57, p < 0.03). In controls, OCN/GAPDH mRNA significantly declined with age (OCN/GAPDH = -0.01 [Age] + 0.82; r = -0.62, p < 0.03). GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
